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KMID : 1155520150100040235
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Anesthesia and Pain Medicine
2015 Volume.10 No. 4 p.235 ~ p.244
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How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles
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Park Jong-Cook
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Abstract
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Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation. A single kinetic profile may be summarized by peak concentration, peak time, half-life and area under the curve. Dosage regimens are designed to confer the maximum desired effects for the required time period with minimal toxicity. Target-controlled infusions use pharmacokinetic models to titrate intravenous anesthetic administration to achieve a desired drug concentration. Context-sensitive half time is used to predict the clinical time course, rather than terminal half-life. It is important that anesthesiologists understand the basic pharmacological principles and apply them in their daily clinical practice. This review discusses the ways in which anesthesiologists can design a patient-specific dosage regimen of intravenous anesthetics by utilizing basic concepts of pharmacokinetics and pharmacodynamics using pharmacokinetic simulations.
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KEYWORD
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Intravenous anesthetics, Pharmacodynamics, Pharmacokinetic parameter, Pharmacokinetics, Target controlled infusion
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